Yes - When I do, I get a message that
"TV Guide is currently not used by any channel, so no update was necessary. You can assign an EPG provider by clicking into the EPG column in the Channels view."
What was unclear was that in the Channels view I needed to click into the column for a specific channel, not the column header. When I did that, It allowed me to download the lineup for all the channels and all looks normal now.